Reproduce “BioProBench: A Corpus and Benchmark for Biological Protocol Reasoning in Autonomous Science” on OpenResearch

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About this paper

Yuyang Liu, Liuzhenghao Lv, Xiancheng Zhang, Jingya Wang Li Yuan, Yonghong Tian

BioProBench tests whether models can answer, order, correct, reason about, and reconstruct biological protocols from provided information. Built from 22,413 protocols across five repositories, it contains 523,784 instances. ProAgent retrieves relevant protocol context and raises Claude-3.7-Sonnet’s generation Step Recall from 42.8% to 62.24%, but this remains incomplete text reconstruction, not evidence of safe laboratory execution.

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