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About this paper

Yunsoo Kim, Yusuf Abdulle, Honghan Wu

A new benchmark, BioHopR, challenges large language models with multi-hop, multi-answer reasoning over the structured PrimeKG biomedical knowledge graph. Evaluations revealed that current state-of-the-art LLMs exhibit limited capabilities in these complex tasks, particularly for two-hop queries, with proprietary models achieving higher precision than open-source alternatives.

Key insights

  • Multi-hop reasoning, particularly the implicit identification of intermediate 'bridge' nodes and alignment of reasoning chains, remains a significant bottleneck for all current LLMs.
  • Specialized open-source biomedical LLMs, while fine-tuned for medical contexts, do not consistently generalize well to complex, structured multi-hop reasoning tasks.
  • LLMs exhibit substantial difficulty in generating exhaustive sets of correct answers for questions with multiple ground truth outcomes, as evidenced by significantly lower performance with multi-answer prompting.

Summary by alphaXiv.

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