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About this paper
Jonathan Feldman, Jeffrey Skolnick
AlphaFold 3 tests whether a compatible donor alignment can improve a target’s predicted structure. The authors place donor-alignment columns at structurally corresponding target positions while retaining the target sequence. Across 94 transplants, median TM-score against experiment rises from 0.442 without alignment to 0.717; shifting the mapping removes the benefit. The test supplies the structural correspondence in advance.
Summary by alphaXiv.
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