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About this paper

Yuxuan Ren, Jiatong Li, Ziqiao Meng, Yatao Bian

STAMP makes molecular fragments addressable so a model can change one part while preserving the rest. It separates fragment identity, attachment atoms, and tree structure; depth-first ordering gives each subtree a contiguous span, and a decoder and compiler support edits. Compatible subtree replacement was strictly valid in 98.5% of trials, versus 23.6% for arbitrary spans; these computational results do not establish clinical benefit.

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