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About this paper
Haowei Lin, Cai Zhou, Xiangxin Zhou
HyInv uses a draft-and-rewrite sampler for protein inverse folding, first generating diverse amino-acid sequences and then revising groups of positions using the surrounding sequence context. Across seven panel–predictor combinations, its mean scTM, a predicted measure of backbone agreement, is 0.875, versus 0.867 for ProteinZero V2 and 0.863 for ProteinMPNN. These computational results concern single-chain backbones, not experimental folding.
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